BioBlue Calm

Mitochondrial energy meets deep nervous system ease.

BioBlue Calm is a soothing, nervous-system supportive formulation that pairs USP-grade Methylene Blue with targeted calming botanicals, magnesium complexes, trace bioactive minerals, and Litewater® Deuterium-Depleted Water — creating a uniquely balanced, calming, and clear energy experience.

Designed for those who want mental clarity and mitochondrial support without intensity, BioBlue Calm promotes a centered, grounded state — ideal for evening wind-down, restorative focus, or stress-heavy days.

This is calm that comes from within the cell, not sedation.

Key Active Ingredients (per 1 ml / ~20 drops)

Why BioBlue Calm Works

BioBlue Calm supports both sides of the energy equation:

• Mitochondria → better ATP efficiency = steady physical and mental energy

• Nervous System → balanced neurotransmitter tone = calm emotional clarity

Where most products try to stimulate or sedate, BioBlue Calm works by supporting the cellular mechanisms that maintain clear thinking, emotional steadiness, and nervous-system resilience.

This is calm that feels alive, not flat.

How BioBlue Calm Feels

Users consistently report:

• Supports ability to wind down in the evening

• Promotes restful sleep without grogginess the following morning

• Quiet, steady mental clarity

• Easier emotional regulation

• Smooth, peaceful energy

• Improved ability to unwind or shift out of “overdrive”

It feels like your mind and body settle into the same rhythm.

What Sets BioBlue Calm Apart

Most methylene blue formulas:

❌ Very energizing and can disrupt sleep, meditation and sense of calmness

❌ Use low-purity, industrial-grade dye

❌ Spike mental energy without supporting nervous system balance

❌ Are dissolved in standard water, diminishing mitochondrial efficiency

❌ Lack co-factors that maintain redox and neurotransmitter stability

BioBlue Calm is engineered differently:

✅ USP Pharmaceutical-Grade Methylene Blue

✅ Botanical adaptogens + calming neurotransmitter modulators

✅ Two forms of Magnesium for synaptic & neuromuscular relaxation

✅ Fulvic acid for enhanced cellular absorption

✅ Trace minerals supporting neural conductivity

✅ Litewater® (10 ppm Deuterium-Depleted Water) for cleaner ATP generation

✅ No fillers, preservatives, alcohol, glycerin, or flavors

This is a nervous system + mitochondrial synergy formula, not a stimulant or sedative.

Is BioBlue Calm For You?

BioBlue Calm is ideal for supporting:

• Evening relaxation or transition routines

• High-stress workdays or emotional overload

• Meditative or creative flow states

• Parasympathetic (rest-and-repair) balance

• Gentle mitochondrial and cognitive support without stimulation

Perfect for:

Creators • High-performers • Nervous system repair work • Shifted sleep schedules • Recovery & integration days • Anyone seeking restorative, grounded clarity

How BioBlue Calm Feels

Users consistently report:

• Quiet, steady mental clarity

• Relaxed focus without fog

• Easier emotional regulation

• Smooth, peaceful energy

• Improved ability to unwind or shift out of “overdrive”

It feels like your mind and body settle into the same rhythm.

BioBlue Calm

Peaceful clarity. Grounded energy. Cellular calm.

BioBlue Calm is a blend of six herbs and minerals combined with pharmaceutical grade methylene blue (USP >99.5%) to help promote relaxation and a sense of calm. This recipe includes all of the same ingredients as our flagship BioBlue product minus nicotinamide mononucleotide (NMN). We decided to remove NMN because while is not a stimulant, it can be stimulating to our physiology given its properties for improving mitochondrial function and energy production.

Between the removal of the NMN and the addition of:

• Ashwagandha

• Valerian

• Passionflower

• Kava

• Magnesium glycinate

• Magnesium L-threonate

...BioBlue Calm functions as a "weighted blanket" for your brain and your nervous system, providing a physiological tranquility in times of stress, anxiety and/or when falling asleep is difficult.

All of the above herbs and minerals contribute to reducing cortisol levels and improved GABA activity in the brain. This alone promotes a deep sense of calm.

Top 10 benefits of methylene blue*:

1. Boosting brain health/cognition

2. Anti-malarial

3. Anti-viral

4. Reduce depression

5. Mitigate/reverse dementia

6. Autism

7. Pain relief

8. Heart health

9. Cancer

10. Chemical poisoning and overdose

Learn more about methylene blue by clicking here

BioBlue Calm ingredients:

Triple distilled biophotonic structured water - not only is the water we utilize clean, purified and distilled, but its energy has been enhanced via direct sunlight in Miron violetglass jars and has been structured, which further upgrades its energy and helps better absorb nutrients.

Methylene blue USP Grade (>99.5%), 1% solution, cGMP manufactured - only the most pure and highest-quality pharmaceutical grade methylene blue is used in BioBlue. Here are a list of some of the health benefits of methylene blue:

• Anti-viral, anti-malarial

• Major brain-boosting properties

• Reduce anxiety, depression, dementia

• Improve overall brain function, cognition, energy, attention/focus and emotional regulation

• Restores mitochondrial health and function by improving oxidative metabolism

• Selectively targets cells that need the most healing first before others

• Cancer cells are targeted first due to their inefficient energy production (which is what methylene blue targets first)

Ashwaganda root (Withania somnifera)* - Ashwagandha is an adaptogenic herb that has been used for centuries in traditional Ayurvedic medicine to promote relaxation, reduce stress, and improve overall well-being. Ashwagandha helps promote calmness by reducing cortisol levels, enhancing GABA activity in the brain, reducing inflammation and contributing as an antioxidant and neuroprotection. 

Valerian rhizome w/ root (Valeriana officinalis)* - Valerian root has been used for centuries as a natural remedy for promoting relaxation and improving sleep. Valerian helps promote calmness by enhancing GABA activity in the brain, modulating serotonin receptors in the brain, modulating adenosine receptors (which promotes relaxation and sleepiness) and reducing cortisol levels.

Passionflower flowering aerial parts (Passiflora incarnata)* - Passionflower has a long history of use as a natural remedy for promoting relaxation and reducing anxiety. Passionflower helps promote calmness by enhancing GABA activity in the brain, modulating serotonin receptors in the brain, contributing as an antioxidant, reducing cortisol levels and modulating of neurotransmitters, such as dopamine and noradrenaline.

Kava rhizome w/ root (Piper methysticum) - Kava is a plant native to the South Pacific islands, where it has been used for centuries in traditional ceremonies and as a beverage with sedative and anxiolytic (anxiety-reducing) effects. The relaxation-promoting effects of kava are primarily attributed to its bioactive compounds, particularly kavalactones. Kava helps promote calmness by  enhancing GABA activity in the brain, modulating of neurotransmitters (i.e., dopamine and noradrenaline), reducing cortisol levels, relaxing muscles and promoting reduced inflammation and antioxidant activity. 

Magnesium glycinate -  is a form of magnesium that is chelated with glycine, an amino acid. This compound is often used as a dietary supplement to address magnesium deficiency, and it is also known for its calming and relaxation-promoting effects. Magnesium glycinate helps promote calmness by its improved absorption (compared to other forms of magnesium), regulation of neurotransmitters (such as GABA), modulation of the HPA axis (which helps reduce cortisol levels), relaxing muscles, regulation of the nervous system (i.e., reducing excitability), reducing inflammation and promoting restful sleep.

Magnesium L-threonate -  is a form of magnesium that is bonded with L-threonate, a compound derived from vitamin C. This specific formulation is notable for its ability to effectively penetrate the blood-brain barrier, leading to increased magnesium levels in the brain. Magnesium L-threonate helps promote calmness by enhanced GABA activity, modulation of NMDA receptors (i.e., reducing hyperactivity in the brain), protection against excitotoxicity, reducing inflammation and enhancing brain function and synaptic activity.

Colloidal gold - Produced by electrolysis that insures highest quality, homogeneity and stability. This method results in a high-quality and well-dispersed colloidal gold product with the highest zeta potential (a high zeta potential indicates that the particles have a strong electrical charge). On top of improving cognitive function, colloidal gold offers additional benefits, such as reducing inflammation, boosting the immune system, reducing aging and improving skin and hair health.

Colloidal silver - notorious for its anti-microbial properties and commonly used for wound care and skin health, colloidal silver also provides anti-inflammatory benefits, strong immune support and has some potential for respiratory support.

Fulvic acid -  known to raise the voltage of your cells, we added the purest fulvic acid in order to enhance the absorption of the ingredients. This means that the methylene blue and NMN may be taken up and better utilized by your cells and tissues. Fulvic acid has other beneficial properties, such as being a powerful antioxidant, anti-inflammatory and promotes improved gut and skin health.

* = organic ingredient

BioBlue Calm is packaged in a Miron violetglass. Miron glass elevates the frequency of enclosed water and nutrients by selectively harnessing beneficial sunlight wavelengths, enhancing their bioavailability and vitality for a more profound and resonant impact on the body.

Recommended Dosing**:

Contraindications & Precautions for Methylene Blue

Contraindications:

1. G6PD Deficiency: Methylene blue is contraindicated in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency, a genetic enzyme disorder. Using methylene blue in individuals with this condition can lead to hemolytic anemia, a potentially severe breakdown of red blood cells.

2. Sulfite Sensitivity: Some methylene blue formulations may contain sulfites, which can trigger allergic reactions in individuals with sulfite sensitivity or allergies.

Precautions:

1. Renal Impairment: Patients with kidney disease or impaired renal function should be monitored carefully when using methylene blue. Dosing adjustments may be necessary due to changes in drug elimination.

2. Hepatic Impairment: Individuals with liver disease or impaired liver function should also be monitored closely, as methylene blue is metabolized by the liver.

3. Pregnancy and Breastfeeding: The safety of methylene blue during pregnancy and breastfeeding is not well established. It should be used with caution in pregnant or nursing women, with careful consideration of the potential risks and benefits.

4. Hypotension: Methylene blue can lower blood pressure. Patients with hypotension (low blood pressure) should be monitored closely, and adjustments to the dosage may be needed.

5. Medication Interactions: Methylene blue may interact with various medications, including serotonergic agents (e.g., certain antidepressants) and monoamine oxidase inhibitors (MAOIs). These interactions can lead to potentially dangerous serotonin syndrome. Inform your healthcare provider about all medications you are taking.

6. Allergies: Individuals with known allergies to methylene blue or other dyes should avoid its use.

7. Oxidative Stress: Methylene blue has antioxidant properties. In conditions where oxidative stress is not a factor, such as in some cancers, its use may not be advisable.

8. Children: While methylene blue is generally considered safe for children when used as a dye for diagnostic purposes, its use as a medication should be under the supervision of a healthcare professional and carefully considered in pediatric patients.

*As outlined in Mark Sloan's book, The Ultimate Guide to Methylene Blue

**These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Information provided by this website or this company is not a substitute for individual medical advice. | ©BioLight, Inc, 2023